ABI’s SNPlex Genotyping System

Malorye A. Branca, ABI Enters High-Throughput Genotyping Market with SNPlex, Bio-IT World. Jan 16 2004.

The SNPlex System makes use of ABI’s 3730xl and 3730 instruments, which are already popular DNA analyzers. It combines the company’s Oligonucleotide Ligation Assays with capillary electrophoresis for detection, ABI GeneMapper software for allele-calling and quality control, and a new data-mining program called BioTrekker.

SNPlex can process up to 48 SNPs (single nucleotide polymorphisms) from a single sample at once. With the 95-capillary system, it can analyze more than 4,500 SNPs, in about 15 minutes, or 400,000 in 24 hours. The company hopes to have the system up to 192 SNPs per sample soon. That would allow one million genotypes, per instrument, per day…

…large-scale studies… [of] diseases like diabetes, schizophrenia, or stroke…require millions of SNPs in hundreds to thousands of patient samples.

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