Genes and Nutrition

The Churchill Effect: "People’s natural inclination to believe that if Winston Churchill lived
to 90 on a diet of marrow bones, champagne and cigars, why not them?"  From a recent Newsweek article on nutrional genomics. 

If marrow bones don’t suit you, then I hear turnips are all the rage in Sweden [Editor: British readers please see the update below].  Or perhaps you’re tired of fads altogether.  Jose Ordovas is tired of diet fads too:

Ordovas, director of the Nutrition and Genomics Laboratory at Tufts
University, believes the era of sweeping dietary recommendations for
the whole population—also sometimes known as fads—may be coming to an
can’t create a diet that’s optimal for everyone, Ordovas says…Within a decade, though, doctors will be able to take genetic profiles
of their patients, identify specific diseases for which they are at
risk and create customized nutrition plans accordingly.

Read the article:

Anne Underwood and Jerry Adler. "Diet and Genes" Newsweek (International Edition) February 7, 2005.

UPDATE:A reader has informed me that the above post is likely to utterly confound British readers:

"Your turnip news is confusing for the British,
since what the English call turnip is a different veg from what the Scots call
turnip. The latter has a different name in England, namely
Swede. Ha!" 

So for the British readers the statement in question should read as follows:

"…If marrow bones don’t suit you, then I hear Swedes are all the rage in Sweden…"

(Thanks for the note Bill!)

Genomics DTC

"Consumer access to predictive testing is gated by primary care providers, who are expected to offer education, informed consent, interpretation of test results, genetic counseling, and follow-on care. There is increasing evidence that this channel is ineffective.

Few primary healthcare providers have the time or specialized training to provide interpretation or counseling. Many are uncomfortable providing such services. While there are specialists trained in genetics and genetic counseling, most are involved in prenatal diagnosis or treatment of genetic disease in children.

Managed care providers and payers have not invested in the resources necessary to deliver quality genetic services at the scale required to meet consumer demand. There is little economic incentive to offer predictive genetic testing given the near-term cost of tests and support services, consumer transience, and the long-term economic benefits that accrue from disease prevention. Moreover, disparities in access to healthcare and limited utilization of the health system for wellness in general, further limit consumer access to these products…

A DTC channel that provides consumers with direct, confidential access to genetic testing services could redress the limitations of the current system."

This from Fred Ledley and Harold Washburn in a December’s DTC Perspectives Magazine.  Fred Ledley, a medical doctor, is one of the few to address the challenges and opportunities of bringing genomics to consumers.  At a conference in Portugal in 2001, Ledley summarized these challenges and opportunities:

"I believe we are on the verge of an explosion of opportunity arising from genomics. The self-knowledge that comes from genetic testing will enable individuals to take control of their own health and make informed decisions about how to protect health and prevent disease. How will our healthcare system respond when consumers begin walking into doctor’s offices and saying "I would like to be tested for APOE", "I would like to be tested to see which drugs are safe".

Some applications of genomics will fit will into medical practice…Few physicians, however, are using genetics to identify predisposition to disease, to counsel patients in how to avoid environmental factors which may be particularly severe risks to that individual, or to choose drugs that are most likely to be safe and effective. There is little tradition of this type of practice within primary care. While the medical community may develop the capacity to deliver some of these services, I believe we will also see the emergence of new mechanisms which enable individuals to decide on their own what genetic tests would help them make decisions about health and wellness, pay for these tests themselves, and control the privacy of their own genetic information.

I believe that one of the most exciting frontiers in medicine is to understand how we will integrate genetic tests [involving] thirty, forty or a hundred thousand genes into clinical practice, how we will respond to consumer interest in genomics, and how we will use this information to achieve real improvements in personal health."

Fred Ledley and Harold Washburn. Can DTC Deliver the Health Benefits of Genomics to the Public? DTC Perspectives Magazine, December 2004.

Fred Ledley. The Future of Genomic Testing. Presentation in Apifarma, Portugal. November 2001. (.doc)

Here is a bio of Fred Ledley.

Genomic Data Privacy

Bradley A. Malin. "An Evaluation of the Current State of Genomic Data Privacy Protection Technology and a Roadmap for the Future." Journal of the American Medical Informatics Association. 12:28-34. (abstract available here, embargo for six months, then will be available here at PubMed Central)…also see here.

Here are some of Malin’s other papers.  See also Carnegie Mellon’s Data Privacy Lab and the Genomic Privacy Project.

Intrasoma Variation

Good news for companies attempting to develop high-throughput genome sequencing technology: the genome sequencing market may be much larger than the size of the human population.  This is to say, we all may need to get our genomes sequenced many times over the course of a lifetime.  At least this is the unproven belief  put forth by Kevin Kelly over at the Edge:

I believe, but cannot prove, that the DNA in your body (and all bodies) varies from part to part…While I have no evidence for my belief right now, it is a provable assertion. It will be shown to be true or false as soon as we have ubiquitous cheap full-genome sequences at discount mall prices. That is, pretty soon. I believe that once we have a constant reading of our individual full DNA (many times over our lives) we will have no end of surprises. I would not be surprised to discover that pet owners accumulate some tiny fragments of their pet’s DNA,which has somehow been laterally transferred via viruses to their own cellular DNA. Or that diary farmers amass noticeable fragments of bovine DNA. Or that the DNA in our limbs somehow drift genetically in a "limby" way, distinct from the variation in the cells in our nervous systems.