$2 million per human genome

Not to be outdone by the recent article published in Nature by scientists at 454 Life Sciences, the polony folks at Harvard toss the following salvo:

The theoretical price of having one’s personal genome sequenced just
fell from the prohibitive $20 million dollars to about $2.2 million,
and the goal is to reduce the amount further–to about $1,000–to make individualized prevention and treatment realistic.

The sharp drop is due to a new DNA sequencing technology developed
by Harvard Medical School (HMS) researchers Jay Shendure, Gregory
Porreca, George Church, and their colleagues, reported on August 4 in
the online edition of Science. The team sequenced the E. coli
bacterial genome at a fraction of the cost of conventional sequencing
using off-the-shelf instruments and chemical reagents. Their technology
appears to be even more accurate and less costly than a commercial DNA
decoding technology reported earlier this week.

Press Release. "A step toward the $1,000 personal genome using readily available lab equipment." EurekaAlert. Aug 4, 2005.

Shendure et al., Accurate Multiplex Polony Sequencing of an Evolved Bacterial Genome,  Science 2005

George Church’s site

FYI: The best discussion of sequencing costs that I am aware is a 2004 paper by Shendure and friends:

Shendure J, Mitra R, Varma C, Church GM (2004) Advanced Sequencing Technologies: Methods and Goals. Nature Reviews of Genetics May;5(5):335-44.

Polonies_2

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