The Incidentalome

A very important paper was published last week in JAMA. The punch line is this: Once the new high throughput diagnostic testing technologies — like massive SNP panels — are widely deployed there will be a significant spike in both true-positive and false-positive results. The implications of this fact are deep and wide.

If you’ve got access to JAMA, check it out. Otherwise, I’ll summarize the important parts the paper later this week.

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Isaac Kohane, Daniel Masys, and Russ Altman. "The Incidentalome: A Threat to Genomic Medicine" JAMA 296(2): 212-215. July 12, 2006. (sorry subscribers only)

July 16, 2006 | Filed Under diagnostics, genetic-testing, genomic-data, microarrays-gene-chips, predictions, sequencing-technology, thought-leaders

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Even if you didn't know it before this moment, getting a personal copy of your genome sequence is a lifestyle choice that you may want to consider.

So are you going to take the personal genomics plunge? How are you going to decide? What are the issues? How are other people making this decision? Who is doing interesting work relevant to these choices? By the way, what is relevant? These are some of the issues this blog is intended to address.