Mexican HapMap Project

Mexico has launched its own genome project:

Mexico has launched a racebased genome project to determine if a genetic basis exists for its growing health crisis. The goal is to glean insights into genetic differences, believed to be unique to its population, that may play a key role in chronic diseases like asthma, diabetes and hypertension.

…The Instituto Nacional de Medicina Genomica (National Genomic Medicine Institute of Mexico, or INMEGEN) will manage the resulting ‘Mexican HapMap’…According to Gerardo Jimenez, director of INMEGEN and the new collaboration, INMEGEN will begin by sampling individuals in six remote regions of Mexico to construct a consensus genetic map that fits the entire Mexican mestizo population, a mixture of Europeans (mainly Spaniards) and Indians. The first objective is to determine if every block of nucleic acid sequence will be alike for all the Mexican groups. “My own prediction,” says Jimenez, “is that we are not going to find huge differences.”

INMEGEN will release newly mined genomic data into the public domain as fast as technology allows, but Jimenez is quick to point out that the measure of the project’s success is not the science, but rather the medicines that come out of it. He also envisions the initiative—the largest genotyping study ever launched in Latin America—having value beyond his country’s borders, informing public health research and drug discovery throughout mestizo countries. To that end, INMEGEN will seek alliances with other Latin American regions in the near future.

Stephen Herrera, Mexico launches bold genome project, Nature Biotechnology. September 2005. (sorry subscribers only) BUT see here!

INMEGEN homepage.

Profile II: International HapMap Project

The International HapMap Project, Nature 426:789 - 796. December 18 2003. (HTML or pdf)

Profile: International HapMap Project

Two recent articles provide profiles of the International HapMap Project (homepage):

Carina Dennis. Special section on human genetics: The rough guide to the genome. Nature 425: 758 - 759.

David Rotman. Genes, Medicine, and the New Race Debate. MIT Technology Review, June 2003.
(only first two paragraphs w/o subscription, but also look here)